The doctors ot the Centers for Disease Control have

recommended that children under 5 who have had o

full series of vaccinations with pneumococcol conjugate

vaccine should now get o dose of Prevnor 13“

to

cover six more strains including the most common one

threatening young children today*

The immune response from this catch-up schedule might be lower for the 6 additional strains (types 1 , 3 , 5 , 6A,

the full 4 doses of Prevnor 13'“. It's not known how medically important this difference is.

Certain strains of the pneumococcal bacteria

can cause serious, invasive disease that is

being seen more frequently today.

Invasive pneumococcal disease includes bocterial

meningitis, which remains a serious risk for

children up to age 5. Pneumococcol meningitis

can couse death and long-term problems,

INDICATION FOR PREVNAR13 ™

• Prevnor 13'“ is a voccine approved for use in children 6 weeks through 5 years of age (prior to the 6th birthday).

• Prevnor 13 " is indicated for active immunization for the prevention of invasive disease caused by 13 strains of

Streptococcus pneumoniae

( 1 , 3 , 4 , 5 , 6A, 6B, 7F, 9V, 1 4 ,1 8C,

19A, 19F, and 23F).

IMPORTANT SAFETY INFORMATION FOR PREVNAR 13'“

• Prevnor 13'" should not be given to anyone with a severe allergic reaction to any component of Prevnor 13'”, Prevnor® (Pneumococcal 7-valent Conjugate Vaccine [Diphtheria

CRM,„ Protein]), or any diphtheria toxoid-containing vaccine.

• Prevnor 13'“ may not protect all individuals receiving the voccine. Children with weakened immune systems moy have a reduced immune response to Prevnor 13™.

A temporary pause of breathing following vaccination has been observed in some infants born prematurely.

• The most commonly reported serious adverse events include bronchiolitis (on infection of the lungs) (0.9%, 1.1%), gastroenteritis (inflammation of the stomach and small

intestine) (0.9%, 0.9% ), and pneumonia (0.9%, 0.5%) for Prevnor 13™ and Prevnot®, respectively.

• The most common side effects are redness, swelling and tenderness at the injection site, fever, decreased appetite, irritability, increased sleep,

and decreased sleep. Any side effects associated with the vaccination should be reported to your child's health care provider.

• Ask your child's health care provider obout the risks and benefits of Prevnar 13™. Only a health core provider con decide if

Prevnor 13 " is right for your child.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or

call I-800-FDA-I088. Please see Brief Summary o f Prescribing Information on reverse side.

Pneumococcol 1 (W e n t Conjugote Voccine

(Oiphtfieria CRM,„ Protein)